BPC-157 vs TB-500: A Research Comparison
BPC-157 and TB-500 are two of the most searched-for research peptides, and they're frequently mentioned in the same breath. But they are distinct compounds, studied in different contexts. This is a factual, research-use comparison — not medical guidance, and not a recommendation for any use in humans.
BPC-157
BPC-157 is a synthetic pentadecapeptide — a chain of 15 amino acids — with a molecular weight of approximately 1419 g/mol. It is widely used as a reference compound in laboratory and in-vitro research.
TB-500
TB-500 is a synthetic fragment related to thymosin beta-4, with a different amino-acid structure and a molecular weight of approximately 888 g/mol. Structurally and mechanistically it is a separate compound from BPC-157.
How they differ
In research terms, the two are studied along different pathways and are not interchangeable. A researcher selects one or the other (or studies them separately) based on the specific model, assay or research question — not because they are substitutes for one another.
| BPC-157 | TB-500 | |
|---|---|---|
| Type | Synthetic pentadecapeptide (15 aa) | Synthetic thymosin β-4 fragment |
| Approx. MW | ~1419 g/mol | ~888 g/mol |
| Format | Lyophilised | Lyophilised |
| Storage | -20°C, desiccated | -20°C, desiccated |
What matters more than the choice
For either compound, the decision that actually affects your research is verification, not branding. The meaningful question is whether the exact lot you receive carries a batch-specific Certificate of Analysis confirming HPLC purity and mass-spec identity. Two vials labelled "BPC-157" can be very different materials if one is verified and one isn't.
Both compounds are supplied lyophilised and stored at -20°C. DNR Peptides currently stocks BPC-157 (TB-500 is referenced here for comparison), and every lot links to its own CoA that you can verify on our site before ordering.
DNR Peptides supplies research peptides for laboratory and research use only. Products are not for human or veterinary use. This article is educational and not medical advice.
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